2024

Evaluating the relationship between glycemic control and bone fragility within the UK Biobank: observational and one-sample Mendelian randomization analyses

Ghatan, S., Koromani, F., Trajanoska, K., Van Velsen, E. F. S., Kavousi, M., Zillikens, M. C., Medina-Gomez, C., Oei, L. & Rivadeneira, F., 1 Nov 2024, In: JBMR Plus. 8, 11, ziae126.

LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response

Mangiavacchi, A., Morelli, G., Reppe, S., Saera-Vila, A., Liu, P., Eggerschwiler, B., Zhang, H., Bensaddek, D., Casanova, E. A., Medina Gomez, C., Prijatelj, V., Della Valle, F., Atinbayeva, N., Izpisua Belmonte, J. C., Rivadeneira, F., Cinelli, P., Gautvik, K. M. & Orlando, V., Sept 2024, In: EMBO Journal. 43, 17, p. 3587-3603 17 p.

Identification of Transcripts with Shared Roles in the Pathogenesis of Postmenopausal Osteoporosis and Cardiovascular Disease

Reppe, S., Gundersen, S., Sandve, G. K., Wang, Y., Andreassen, O. A., Medina-Gomez, C., Rivadeneira, F., Utheim, T. P., Hovig, E. & Gautvik, K. M., 20 May 2024, In: International Journal of Molecular Sciences. 25, 10, 5554.

Bone health index in the assessment of bone health: The Generation R Study

Prijatelj, V., Grgic, O., Uitterlinden, A. G., Wolvius, E. B., Rivadeneira, F. & Medina-Gomez, C., May 2024, In: Bone. 182, 117070.

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Mulder, R. H., Kraaij, R., Schuurmans, I. K., Frances-Cuesta, C., Sanz, Y., Medina-Gomez, C., Duijts, L., Rivadeneira, F., Tiemeier, H., Jaddoe, V. W. V., Felix, J. F. & Cecil, C. A. M., May 2024, In: Brain, Behavior, and Immunity. 118, p. 117-127 11 p.

Association between BMD and coronary artery calcification: an observational and Mendelian randomization study

Lu, H., Lary, C. W., Hodonsky, C. J., Peyser, P. A., Bos, D., van der Laan, S. W., Miller, C. L., Rivadeneira, F., Kiel, D. P., Kavousi, M. & Medina-Gomez, C., Apr 2024, In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 39, 4, p. 443-452 10 p.

Oral microbiota of adolescents with dental caries: A systematic review

Veenman, F., van Dijk, A., Arredondo, A., Medina-Gomez, C., Wolvius, E., Rivadeneira, F., Àlvarez, G., Blanc, V. & Kragt, L., Apr 2024, In: Archives of Oral Biology. 161, 105933.

Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Ghatan, S., van Rooij, J., van Hoek, M., Boer, C. G., Felix, J. F., Kavousi, M., Jaddoe, V. W., Sijbrands, E. J. G., Medina-Gomez, C., Rivadeneira, F. & Oei, L., 10 Jan 2024, (E-pub ahead of print) In: Genome Medicine. 16, 1, 10.

2023

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

Budu-Aggrey, A., Kilanowski, A., Sobczyk, M. K., Shringarpure, S. S., Mitchell, R., Reis, K., Reigo, A., Mägi, R., Nelis, M., Tanaka, N., Brumpton, B. M., Thomas, L. F., Sole-Navais, P., Flatley, C., Espuela-Ortiz, A., Herrera-Luis, E., Lominchar, J. V. T., Bork-Jensen, J., Marenholz, I. & Arnau-Soler, A. & 112 others, , 4 Oct 2023, In: Nature Communications. 14, 1, 6172.

A second update on mapping the human genetic architecture of COVID-19

The COVID-19 Host Genetics Initiative, 7 Sept 2023, In: Nature. 621, 7977, p. E7-E26

Bi-Directional Interactions between Glucose-Lowering Medications and Gut Microbiome in Patients with Type 2 Diabetes Mellitus: A Systematic Review

Li, R., Shokri, F., Rincon, A. L., Rivadeneira, F., Medina-Gomez, C. & Ahmadizar, F., 1 Aug 2023, In: Genes. 14, 8, 1572.

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

Medina-Gomez, C., Mullin, B. H., Chesi, A., Prijatelj, V., Kemp, J. P., Shochat-Carvalho, C., Trajanoska, K., Wang, C., Joro, R., Evans, T. E., Schraut, K. E., Li-Gao, R., Ahluwalia, T. S., Zillikens, M. C., Zhu, K., Mook-Kanamori, D. O., Evans, D. S., Nethander, M., Knol, M. J. & Thorleifsson, G. & 38 others, , 4 Jul 2023, In: Communications Biology. 6, 1, 691.

Advanced Glycation End Products (AGEs) in Diet and Skin in Relation to Stool Microbiota: The Rotterdam Study

Chen, J., Radjabzadeh, D., Medina-Gomez, C., Voortman, T., van Meurs, J. B. J., Ikram, M. A., Uitterlinden, A. G., Kraaij, R. & Zillikens, M. C., Jun 2023, In: Nutrients. 15, 11, 2567.

Association of Bone Mineral Density and Dementia: The Rotterdam Study

Xiao, T., Ghatan, S., Mooldijk, S. S., Trajanoska, K., Oei, L., Gomez, M. M., Ikram, M. K., Rivadeneira, F. & Ikram, M. A., 16 May 2023, In: Neurology. 100, 20, p. e2125-e2133

Novel Genetic Determinants of Dental Maturation in Children

Grgic, O., Prijatelj, V., Dudakovic, A., Vucic, S., Dhamo, B., Trajanoska, K., Monnereau, C., Zrimsek, M., Gautvik, K. M., Reppe, S., Shimizu, E., Timpson, N. J., Jaddoe, V. W. V., Jarvelin, M. R., Evans, D., Uitterlinden, A. G., Ongkosuwito, E. M., van Wijnen, A. J., Medina-Gomez, C. & Rivadeneira, F. & 1 others, , Mar 2023, In: Journal of Dental Research. 102, 3, p. 349-356 8 p.

The gut microbiome and child mental health: A population-based study

Kraaij, R., Schuurmans, I. K., Radjabzadeh, D., Tiemeier, H., Dinan, T. G., Uitterlinden, A. G., Hillegers, M., Jaddoe, V. W. V., Duijts, L., Moll, H., Rivadeneira, F., Medina-Gomez, C., Jansen, P. W. & Cecil, C. A. M., Feb 2023, In: Brain, Behavior, and Immunity. 108, p. 188-196 9 p.

Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants

Young, K. L., Fisher, V., Deng, X., Brody, J. A., Graff, M., Lim, E., Lin, B. M., Xu, H., Amin, N., An, P., Aslibekyan, S., Fohner, A. E., Hidalgo, B., Lenzini, P., Kraaij, R., Medina-Gomez, C., Prokić, I., Rivadeneira, F., Sitlani, C. & Tao, R. & 42 others, , 12 Jan 2023, In: Human Genetics and Genomics Advances. 4, 1, 100163.

2022

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z. & Xue, C. & 519 others, , 27 Dec 2022, In: Genome Biology. 23, 1, p. 268 1 p., 268.

A saturated map of common genetic variants associated with human height

Yengo, L., Vedantam, S., 23andMe Inc., VA Million Veteran Program, DiscovEHR and MyCode Community Health Initiative, eMERGE (Electronic Medical Records and Genomics Network) Consortium, The LifeLines Cohort Study, The PRACTICAL Consortium, Understanding Society Scientific Group, Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D. & Graham, S. E. & 37 others, , 27 Oct 2022, In: Nature. 610, 7933, p. 704-712 9 p.

The genetic overlap between osteoporosis and craniosynostosis

Kague, E., Medina-Gomez, C., Boyadjiev, S. A. & Rivadeneira, F., 26 Sept 2022, In: Frontiers in Endocrinology. 13, 1020821.

A first update on mapping the human genetic architecture of COVID-19

The COVID-19 Host Genetics Initiative, AncestryDNA COVID-19 Research Study, BelCovid, Biobanque Quebec COVID-19, CCHC COVID-19 GAWS, CHOP CAG, The Colorado Center for Personalized Medicine, Coronagenes, Egypt hgCOVID hub, EraCORE, The Estonian Biobank Research Team, EXCEED, FinnGen Consortium, Functional Host Genomics in Infectious Diseases (FHoGID), GCAT Genomes For Life, GEN-COVID Multicenter Study Group, Generation Scotland, Genes & Health Research Team, Genes for Good & Genome-wide assessment of the gene variants associated with severe COVID-19 phenotype in Iran & 19 others, , 4 Aug 2022, In: Nature. 608, 7921, p. E1-E10

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Ramdas, S., Judd, J., Million Veterans Program, Global Lipids Genetics Consortium, Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H. & Ntalla, I. & 34 others, , 4 Aug 2022, In: American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.

Genetic Evidence for a Causal Role of Serum Phosphate in Coronary Artery Calcification: The Rotterdam Study

Campos-Obando, N., Bosman, A., Kavousi, M., Medina-Gomez, C., van der Eerden, B. C. J., Bos, D., Franco, O. H., Uitterlinden, A. G. & Zillikens, M. C., 2 Aug 2022, In: Journal of the American Heart Association. 11, 15, e023024.

Whole-genome sequencing reveals host factors underlying critical COVID-19

Kousathanas, A., Pairo-Castineira, E., GenOMICC co-investigators, COVID-19 Human Genetics Initiative, 23andMe investigators, Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S. & Wang, B. & 27 others, , 7 Jul 2022, In: Nature. 607, 7917, p. 97-103 7 p.

Serum Phosphate, BMI, and Body Composition of Middle-Aged and Older Adults: A Cross-Sectional Association Analysis and Bidirectional Mendelian Randomization Study

Bosman, A., Campos-Obando, N., Medina-Gomez, C., Voortman, T., Uitterlinden, A. G. & Zillikens, M. C., 1 Jan 2022, In: Journal of Nutrition. 152, 1, p. 276-285 10 p.

2021

The power of genetic diversity in genome-wide association studies of lipids

Graham, S. E., Clarke, S. L., VA Million Veteran Program, Global Lipids Genetics Consortium, Wu, K. H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R. & Ekoru, K. & 32 others, , 23 Dec 2021, In: Nature. 600, 7890, p. 675-679 5 p.

Mapping the human genetic architecture of COVID-19

The COVID-19 Host Genetics Initiative, 16 Dec 2021, In: Nature. 600, 7889, p. 472-477 6 p.

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Foessl, I., Bassett, J. H. D., Bjørnerem, Å., Busse, B., Calado, Â., Chavassieux, P., Christou, M., Douni, E., Fiedler, I. A. K., Fonseca, J. E., Hassler, E., Högler, W., Kague, E., Karasik, D., Khashayar, P., Langdahl, B. L., Leitch, V. D., Lopes, P., Markozannes, G. & McGuigan, F. E. A. & 14 others, , 1 Dec 2021, In: Frontiers in Endocrinology. 12, 720728.

CYP11B1 variants influence skeletal maturation via alternative splicing

Grgic, O., Gazzara, M. R., Chesi, A., Medina-Gomez, C., Cousminer, D. L., Mitchell, J. A., Prijatelj, V., de Vries, J., Shevroja, E., McCormack, S. E., Kalkwarf, H. J., Lappe, J. M., Gilsanz, V., Oberfield, S. E., Shepherd, J. A., Kelly, A., Mahboubi, S., Faucz, F. R., Feelders, R. A. & de Jong, F. H. & 10 others, , 9 Nov 2021, In: Communications Biology. 4, 1, 1274.

A comparison of genotyping arrays

Verlouw, J. A. M., Clemens, E., de Vries, J. H., Zolk, O., Verkerk, A. J. M. H., am Zehnhoff-Dinnesen, A., Medina-Gomez, C., Lanvers-Kaminsky, C., Rivadeneira, F., Langer, T., van Meurs, J. B. J., van den Heuvel-Eibrink, M. M., Uitterlinden, A. G. & Broer, L., Nov 2021, In: European Journal of Human Genetics. 29, 11, p. 1611-1624 14 p.

The Polygenic and Monogenic Basis of Paediatric Fractures

Ghatan, S., Costantini, A., Li, R., De Bruin, C., Appelman-Dijkstra, N. M., Winter, E. M., Oei, L. & Medina-Gomez, C., Oct 2021, In: Current Osteoporosis Reports. 19, 5, p. 481-493 13 p.

The Gut Microbiome: a New Frontier in Musculoskeletal Research

Li, R., Boer, C. G., Oei, L. & Medina-Gomez, C., Jun 2021, In: Current Osteoporosis Reports. 19, 3, p. 347-357 11 p.

An ARHGAP25 variant links aberrant Rac1 function to early-onset skeletal fragility

Mäkitie, R. E., Henning, P., Jiu, Y., Kämpe, A., Kogan, K., Costantini, A., Välimäki, V. V., Medina-Gomez, C., Pekkinen, M., Salusky, I. B., Schalin-Jäntti, C., Haanpää, M. K., Rivadeneira, F., Bassett, J. H. D., Williams, G. R., Lerner, U. H., Pereira, R. C., Lappalainen, P. & Mäkitie, O., 6 May 2021, In: JBMR Plus. 5, 7, e10509.

A population-based study on associations of stool microbiota with atopic diseases in school-age children

Hu, C., van Meel, E. R., Medina-Gomez, C., Kraaij, R., Barroso, M., Kiefte-de Jong, J., Radjabzadeh, D., Pasmans, S. G. M. A., de Jong, N. W., de Jongste, J. C., Moll, H. A., Nijsten, T., Rivadeneira, F., Pardo, L. M. & Duijts, L., 13 Apr 2021, In: Journal of Allergy and Clinical Immunology. 148, 2, p. 612-620 9 p.

Microbiomics, Metabolomics, Predicted Metagenomics, and Hepatic Steatosis in a Population-Based Study of 1,355 Adults

Alferink, L., Radjabzadeh, D., Erler, N., Vojinovic, D., Medina Gomez, M., Uitterlinden, A., de Knegt, R., Amin, N., Ikram, A., Janssen, H., Jong, J., Metselaar, H., Duijn, C., Kraaij, R. & Darwish Murad, S., Mar 2021, In: Hepatology. 73, 3, p. 968-982 15 p.

Large-scale association analyses identify host factors influencing human gut microbiome composition

Kurilshikov, A., Medina Gomez, M., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, C., Garay, J., Finnicum, C., Liu, X., Zhernakova, D., Bonder, M., Hansen, T., Frost, F., Ruhlemann, M., Turpin, W., Moon, J., Kim, H., Lull, K. & Barkan, E. & 84 others, , Feb 2021, In: Nature Genetics. 53, 2, p. 156-165 10 p.

Genome-wide association study identifies 48 common genetic variants associated with handedness

Cuellar-Partida, G., Tung, J., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, O., Barroso, I., Beckmann, J., Boks, M. P., Boomsma, D., Boyd, H., Breteler, M., Campbell, H., Chasman, D., Cherkas, L., Davies, G., de Geus, E., Deary, I., Deloukas, P. & Dick, D. & 98 others, , Jan 2021, In: Nature Human Behaviour. 5, 1, p. 59-70 12 p.

2020

Distinct Subsets of Noncoding RNAs Are Strongly Associated With BMD and Fracture, Studied in Weight-Bearing and Non–Weight-Bearing Human Bone

Gautvik, K., Günther, C., Prijatelj, V., Medina Gomez, M., Shevroja, E., Rad, L., Yazdani, M., Lindalen, E., Valland, H., Gautvik, V., Olstad, O., Holden, M., Rivadeneira, F., Utheim, T. & Reppe, S., 2020, In: Journal of Bone and Mineral Research. 35, 6, p. 1065-1076 12 p.

Diversity, compositional and functional differences between gut microbiota of children and adults

Radjabzadeh, D., Boer, C., Beth, S., van der Wal, P., Jong, J., Jansen, M., Konstantinov, S., Peppelenbosch, M., Hays, J., Jaddoe, V., Ikram, A., Rivadeneira, F., van Meurs, J., Uitterlinden, A., Medina Gomez, M., Moll, H. & Kraaij, R., 2020, In: Scientific Reports. 10

Genetic basis of falling risk susceptibility in the UK Biobank Study

Trajanoska, K., Seppala, L., Medina Gomez, M., Hsu, Y., Zhou, S., Schoor, N., de Groot, L., Karasik, D., Richards, J., Kiel, D., Uitterlinden, A., Perry, J., van de Velde, N., Day, F. & Rivadeneira, F., 2020, In: Communications Biology. 3, 1, 543.

Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity

Yaghootkar, H., Zhang, Y., Spracklen, C., Karaderi, T., Huang, L., Bradfield, J., Schurmann, C., Fine, R., Preuss, M., Kutalik, Z., Wittemans, L., Lu, Y., Metz, S., Willems, S., Li-Gao, R., Grarup, N., Wang, S., Molnos, S., Sandoval-Zárate, A. & Nalls, M. & 96 others, , 2020, In: Diabetes. 69, 12, p. 2806-2818 13 p.

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Vogelezang, S., Bradfield, J., Ahluwalia, T., Curtin, J., Lakka, T., Grarup, N., Monnereau, C., Medina Gomez, M., Rivadeneira, F., Uitterlinden, A., Grant, S., Jaddoe, V. & Felix, J., 2020, In: PLoS Genetics (online). 16, 10, e1008718.

Skeletal maturation in relation to ethnic background in children of school age: The Generation R Study

Grgic, O., Shevroja, E., Dhamo, B., Uitterlinden, A., Wolvius, E., Rivadeneira, F. & Medina Gomez, M., 2020, In: Bone. 132, Unsp 115180.

2019

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetics Consortium, GoT2D Genes Consortium, The InterAct consortium, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Justice, A. E., Karaderi, T., Highland, H. M., Young, K. L., Graff, M., Lu, Y., Turcot, V., Auer, P. L., Fine, R. S. & Guo, X. & 42 others, , Mar 2019, In: Nature Genetics. 51, 3, p. 452-469 18 p.

An atlas of genetic influences on osteoporosis in humans and mice

Morris, J., Kemp, J., Youlten, S., Laurent, L., Logan, J., Chai, R., Medina Gomez, M., Trajanoska, K., Evans, D. & Richards, J., 2019, In: Nature Genetics. 51, 2, p. 258-266 9 p.

Associations of autozygosity with a broad range of human phenotypes

Clark, D., Okada, Y., Moore, K., Mason, D., Pirastu, N., Gandin, I., Medina Gomez, M., Felix, J., Jaddoe, V., Rietveld, N., Kubo, M. & Wilson, J., 2019, In: Nature Communications. 10, 4957.

Disentangling the genetics of lean mass

Karasik, D., Zillikens, M. C., Hsu, Y., Aghdassi, A., Akesson, K., Amin, N., Broer, L., Campos Obando, N., Enneman, A., Estrada Gil, K., Hofman, B., Kloth, J., Medina Gomez, M., Oostra, B., Rivadeneira, F., Stolk, L., Uitterlinden, A., Duijn, C., Kiel, D. & Ohlsson, C., 2019, In: American Journal of Clinical Nutrition. 109, 2, p. 276-287 12 p.

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

Spracklen, C., Karaderi, T., Yaghootkar, H., Schurmann, C., Fine, R., Kutalik, Z., Amin, N., Broer, L., Demirkan, A., Duijn, C., Ikram, A., Medina Gomez, M., Prokic, I., Uitterlinden, A., Loos, R. & Mohlke, K., 2019, In: American Journal of Human Genetics. 105, 1, p. 15-28 14 p.

Femoral stress is prominently associated with fracture risk in children: The Generation R Study

Grgic, O., Rivadeneira, F., Shevroja, E., Trajanoska, K., Jaddoe, V., Uitterlinden, A., Beck, T., Wolvius, E. & Medina Gomez, M., 2019, In: Bone. 122, p. 150-155 6 p.

Fractures in school age children in relation to sex and ethnic background: The Generation R Study

Grgic, O., Chung, K., Shevroja, E., Trajanoska, K., Uitterlinden, A., Wolvius, E., Rivadeneira, F. & Medina Gomez, M., 2019, In: Bone. 121, p. 227-231 5 p.

Intestinal microbiome composition and its relation to joint pain and inflammation

Boer, C., Radjabzadeh, D., Medina Gomez, M., Garmaeva, S., Schiphof, D., Arp, P., Koet, T., Kurilshikov, A., Fu, J., Ikram, A., Bierma – Zeinstra, S., Uitterlinden, A., Kraaij, R., Zhernakova, A. & van Meurs, J., 2019, In: Nature Communications. 10, 4881.

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Haworth, S., Shapland, C., Hayward, C., Prins, B., Felix, J., Medina Gomez, M., Rivadeneira, F., Wang, C., Ahluwalia, T., Vrijheid, M., Guxens Junyent, M., Sunyer, J., Tachmazidou, I., Walter, K., Iotchkova, V., Jackson, A., Cleal, L., Huffmann, J., Min, J. & Sass, L. & 221 others, , 2019, In: Nature Communications. 10, 357.

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Warrington, N., Beaumont, R., Horikoshi, M., Day, F., Helgeland, O., Laurin, C., Medina Gomez, M., Kooijman, M., Rivadeneira, F., Hofman, B., Felix, J., Jaddoe, V. & Uitterlinden, A., 2019, In: Nature Genetics. 51, 5, p. 804-+

Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease

Marouli, E., Del Greco, M., Astley, C., Yang, J., Ahmad, S., Berndt, S., Caulfield, M., Evangelou, E., McKnight, B., Medina Gomez, M., van Vliet-Ostaptchouk, J., Warren, H., Zhu, Z., Hirschhorn, J., Loos, R., Kutalik, Z. & Deloukas, P., 2019, In: Communications Biology. 2, 119.

Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry

Hsu, Y., Estrada Gil, K., Evangelou, E., Ackert-Bicknell, C., Akesson, K., Beck, T., Medina Gomez, M., Trajanoska, K., Uitterlinden, A., Zillikens, M. C., Rivadeneira, F., Kiel, D. & Karasik, D., 2019, In: Journal of Bone and Mineral Research. 34, 7, p. 1284-1296 13 p., UNSP e3698.

Skewed X-inactivation is common in the general female population

Shvetsova, E., Sofronova, A., Monajemi, R., Gagalova, K., Draisma, H., White, S., van Meurs, J., Duijn, C., Hofman, B., Uitterlinden, A., Jhamai, M., Verbiest, M., Verkerk, M., van Rooij, J., Isaacs, A., Leeuwen, E., Oven, M., Karssen, L., Koval, S. & Rivadeneira, F. & 6 others, , 2019, In: European Journal of Human Genetics. 27, 3, p. 455-465 11 p.

WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

Nersisyan, L., Nikoghosyan, M., Francioli, L., Menelaou, A., Pulit, S., Elbers, C., Leeuwen, E., Karssen, L., Amin, N., Rivadeneira, F., Isaacs, A., Hofman, B., Uitterlinden, A., Duijn, C., Oven, M., Kayser, M., Estrada Gil, K., Koval, S., Medina Gomez, M. & Oostra, B. & 2 others, , 2019, In: Scientific Reports. 9, 18758.

2018

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetics Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Understanding Society Scientific Group, Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T. & Giri, A. & 48 others, , Jan 2018, In: Nature Genetics. 50, 1, p. 26-41 16 p.

[Erratum:] Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

Manousaki, D., Dudding, T., Haworth, S., Hsu, Y., Liu, C., Medina Gomez, M., Voortman, T., van der Velde, N., Melhus, H., Robinson-Cohen, C., Cousminer, D., Nethander, M., Vandenput, L., Noordam, R., Forgetta, V., Greenwood, C., Biggs, M., Psaty, B., Rotter, J. & Zemel, B. & 33 others, , 2018, In: American Journal of Human Genetics. 103, 6, p. 1053

Ancestry and dental development: A geographic and genetic perspective

Dhamo, B., Kragt, L., Grgic, O., Vucic, S., Medina Gomez, M., Rivadeneira, F., Jaddoe, V., Wolvius, E. & Ongkosuwito, E., 2018, In: American Journal of Physical Anthropology. 165, 2, p. 299-308 10 p.

Characterization of expression and alternative splicing of the gene cadherin-like and PC esterase domain containing 1 (Cped1)

Maynard, R., Godfrey, D., Medina Gomez, M. & Ackert-Bicknell, C., 2018, In: Gene. 674, p. 127-133 7 p.

Consortium-based genome-wide meta-analysis for childhood dental caries traits

Haworth, S., Shungin, D., van der Tas, J., Vucic, S., Medina Gomez, M., Yakimov, V., Feenstra, B., Shaffer, J., Lee, M., Standl, M., Thiering, E., Wang, C., Bonnelykke, K., Waage, J., Jessen, L., Norrisgaard, P., Joro, R., Seppala, I., Raitakari, O. & Dudding, T. & 23 others, , 2018, In: Human Molecular Genetics. 27, 17, p. 3113-3127 15 p.

Genome-wide association study identifies nine novel loci for 2D: 4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero

Warrington, N., Shevroja, E., Hemani, G., Hysi, P., Jiang, Y., Auton, A., Boer, C., Mangino, M., Wang, C., Kemp, J., McMahon, G., Medina Gomez, M., Hickey, M., Trajanoska, K., Wolke, D., Ikram, A., Montgomery, G., Felix, J., Wright, M. & Mackey, D. & 10 others, , 2018, In: Human Molecular Genetics. 27, 11, p. 2025-2038 14 p.

Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density

Alonso, N., Estrada Gil, K., Albagha, O., Herrera Duran, L., Reppe, S., Olstad, O., Gautvik, K., Ryan, N., Evans, K., Nielson, C., Hsu, Y., Kiel, D., Markozannes, G., Ntzani, E., Evangelou, E., Feenstra, B., Liu, X., Melbye, M., Masi, L. & Brandi, M. & 41 others, , 2018, In: Annals of the Rheumatic Diseases. 77, 3

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

Medina Gomez, M., Kemp, J., Trajanoska, K., Luan, J., Chesi, A., Ahluwalia, T., Mook, D., Ham, A., Hartwig, F., Evans, D., Joro, R., Prokic, I., Zheng, H., Zhu, K., Atalay, M., Liu, C., Nethander, M., Broer, L., Porleifsson, G. & Mullin, B. & 69 others, , 2018, In: American Journal of Human Genetics. 102, 1, p. 88-102 15 p.

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative

Wang, J., Kurilshikov, A., Radjabzadeh, D., Turpin, W., Croitoru, K., Bonder, M., Jackson, M., Medina Gomez, M., Frost, F., Homuth, G., Ruehlemann, M., Hughes, D., Kim, H., Spector, T., Bell, J., Steves, C., Timpson, N., Franke, A., Wijmenga, C. & Meyer, K. & 6 others, , 2018, In: Microbiome. 6, 101.

Sarcopenia and Its Clinical Correlates in the General Population: The Rotterdam Study

Trajanoska, K., Schoufour, J., Darweesh, S., Benz Inalaf, G., Medina Gomez, M., Alferink, L., Lahousse, L., Brusselle, G., Stricker, B., Darwish Murad, S., Zillikens, M. C., Uitterlinden, A., Ikram, A., Franco Duran, O. & Rivadeneira, F., 2018, In: Journal of Bone and Mineral Research. 33, 7, p. 1209-1218 10 p.

2017

Rare and low-frequency coding variants alter human adult height

EPIC-InterAct Consortium, ReproGen Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium, The MAGIC Investigators, Marouli, E., Graff, M., Medina-Gomez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., Rüeger, S. & Thorleifsson, G. & 43 others, , 1 Feb 2017, In: Nature. 542, 7640, p. 186-190 5 p.

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Zillikens, M. C., Demissie, S., Hsu, Y., Yerges-Armstrong, L., Chou, W., Stolk, L., Livshits, G., Broer, L., Johnson, T., Koller, D., Kutalik, Z., Luan, J., Malkin, I., Ried, J., Smith, A., Thorleifsson, G., Vandenput, L., Zhao, J., Zhang, W. & Aghdassi, A. & 173 others, , 2017, In: Nature Communications. 8, 80.

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

Manousaki, D., Dudding, T., Haworth, S., Hsu, Y., Liu, C., Medina Gomez, M., Voortman, T., van der Velde, N., Melhus, H., Robinson-Cohen, C., Cousminer, D., Nethander, M., Vandenput, L., Noordam, R., Forgetta, V., Greenwood, C., Biggs, M., Psaty, B., Rotter, J. & Zemel, B. & 33 others, , 2017, In: American Journal of Human Genetics. 101, 2, p. 227-238 12 p.

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

Tachmazidou, I., Suveges, D., Min, J., Ritchie, G., Steinberg, J., Walter, K., Iotchkova, V., Schwartzentruber, J., Huang, J., Memari, Y., McCarthy, S., Crawford, A., Bombieri, C., Cocca, M., Farmaki, A., Gaunt, T., Jousilahti, P., Kooijman, M., Lehne, B. & Malerba, G. & 83 others, , 2017, In: American Journal of Human Genetics. 100, 6, p. 865-884 20 p.

2016

Disentangling the Heterogeneity of Bone Accrual

Medina Gomez, M., 31 May 2016, Erasmus Universiteit Rotterdam (EUR).

A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways

Bustamante, M., Standl, M., Bassat, Q., Vilor-Tejedor, N., Medina Gomez, M., Bonilla, C., Ahluwalia, T., Bacelis, J., Bradfield, J., Tiesler, C., Rivadeneira, F., Ring, S., Vissing, N., Jugessur, A., Mentch, F., Ballester, F., Kriebel, J., Jong, J., Wolsk, H. & Llop, S. & 18 others, , 2016, In: Human Molecular Genetics. 25, 18, p. 4142 4127.

Bone Mass and Strength in School-Age Children Exhibit Sexual Dimorphism Related to Differences in Lean Mass: The Generation R Study

Medina Gomez, M., Heppe, D., Yin, J.-L., Trajanoska, K., Uitterlinden, A., Beck, T., Jaddoe, V. & Rivadeneira, F., 2016, In: Journal of Bone and Mineral Research. 31, 5, p. 1099-1106 8 p.

Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children

Neumann, A., Pappa, I., Lahey, B., Verhulst, F., Medina Gomez, M., Jaddoe, V., Bakermans-Kranenburg, M., Moffitt, T., van IJzendoorn, M. & Tiemeier, H., 2016, In: Journal of the American Academy of Child and Adolescent Psychiatry. 55, 12, p. 1038-1045 8 p.

The case for genome-wide association studies of bone acquisition in paediatric and adolescent populations

Kemp, J., Medina Gomez, M., Tobias, J., Rivadeneira, F. & Evans, D., 2016, In: Bonekey Reports. 5, 796.

2015

Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci

Reppe, S., Wang, Y., GEFOS Consortium, Thompson, W. K., McEvoy, L. K., Schork, A. J., Zuber, V., LeBlanc, M., Bettella, F., Mills, I. G., Desikan, R. S., Djurovic, S., Gautvik, K. M., Dale, A. M., Andreassen, O. A., Oei, L., Amin, N., Li, G., Aulchenko, Y. S. & Castano-Betancourt, M. & 13 others, , 1 Dec 2015, In: PLoS ONE. 10, 12, e0144531.

Genetic studies of body mass index yield new insights for obesity biology

ADIPOGen Consortium, The AGEN-BMI Working Group, The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The GLGC, ICBP Consortium, The MAGIC Investigators, The MuTHER Consortium, The MIGen Consortium, The PAGE Consortium, The GENIE Consortium, The International Endogene Consortium, Locke, A. E., Kahali, B., The LifeLines Cohort Study, ReproGen Consortium, Berndt, S. I., Justice, A. E., Pers, T. H. & Day, F. R. & 50 others, , 11 Feb 2015, In: Nature. 518, 7538, p. 197-206 10 p.

BMD Loci Contribute to Ethnic and Developmental Differences in Skeletal Fragility across Populations: Assessment of Evolutionary Selection Pressures

Medina Gomez, M., Chesi, A., Heppe, D., Zemel, B., Yin, J.-L., Kalkwarf, H., Hofman, B., Lappe, J., Kelly, A., Kayser, M., Oberfield, S., Gilsanz, V., Uitterlinden, A., Shepherd, J., Jaddoe, V., Grant, S., Lao Grueso, O. & Rivadeneira, F., 2015, In: Molecular Biology and Evolution. 32, 11, p. 2961-2972 12 p.

Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study

Medina Gomez, M., Felix, J., Estrada Gil, K., Peters, M., Herrera Duran, L., Kruithof, C., Duijts, L., Hofman, B., Duijn, C., Uitterlinden, A., Jaddoe, V. & Rivadeneira, F., 2015, In: European Journal of Epidemiology. 30, 4, p. 317-330 14 p.

Does fetal smoke exposure affect childhood bone mass? The Generation R Study

Heppe, D., Medina Gomez, M., Hofman, B., Rivadeneira, F. & Jaddoe, V., 2015, In: Osteoporosis International. 26, 4, p. 1319-1329 11 p.

Estimation of Genetic Relationships Between Individuals Across Cohorts and Platforms: Application to Childhood Height

Fedko, I., Hottenga, J., Medina Gomez, M., Pappa, I., Beijsterveld, C., Ehli, E., Davies, G., Rivadeneira, F., Tiemeier, H., Swertz, M., Middeldorp, C., Bartels, M. & Boomsma, D., 2015, In: Behavior Genetics. 45, 5, p. 514-528 15 p.

Genome-Wide Association Study in an Admixed Case Series Reveals IL12A as a New Candidate in Behcet Disease

Kappen, J., Medina Gomez, M., van Hagen, P. M., Stolk, L., Estrada Gil, K., Rivadeneira, F., Uitterlinden, A., Stanford, M., Ben-Chetrit, E., Wallace, G., Soylu, M. & van Laar, J., 2015, In: PLoS One (print). 10, 3

Improving accuracy of rare variant imputation with a two-step imputation approach

Moller, G., Medina Gomez, M., Uitterlinden, A., Rivadeneira, F. & Estrada Gil, K., 2015, In: European Journal of Human Genetics. 23, 3, p. 395-400 6 p.

Infant dietary patterns and bone mass in childhood: the Generation R Study

Hooven, E., Heppe, D., Jong, J., Medina Gomez, M., Moll, H., Hofman, B., Jaddoe, V., Rivadeneira, F. & Franco Duran, O., 2015, In: Osteoporosis International. 26, 5, p. 1595-1604 10 p.

Methylation of Bone SOST, Its mRNA, and Serum Sclerostin Levels Correlate Strongly With Fracture Risk in Postmenopausal Women

Reppe, S., Noer, A., Grimholt, R., Halldorsson, B., Medina Gomez, M., Gautvik, V., Olstad, O., Berg, J., Datta, H., Estrada Gil, K., Hofman, B., Uitterlinden, A., Rivadeneira, F., Lyle, R., Collas, P. & Gautvik, K., 2015, In: Journal of Bone and Mineral Research. 30, 2, p. 249-256 8 p.

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, T., Justice, A., Graff, M., Barata, L., Feitosa, M., Chu, S., Czajkowski, J., Esko, T., Fall, T., Kilpelainen, T., Lu, Y., Magi, R., Mihailov, E., Pers, T., Rueger, S., Teumer, A., Ehret, G., Ferreira, T., Heard-Costa, N. & Karjalainen, J. & 419 others, , 2015, In: PLoS Genetics (online). 11, 10

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

Zheng, H., Forgetta, V., Hsu, Y., Estrada Gil, K., Rosello-Diez, A., Leo, P., Dahia, C., Park-Min, K., Tobias, J., Kooperberg, C., Kleinman, A., Styrkarsdottir, U., Liu, C., Uggla, C., Evans, D., Nielson, C., Walter, K., Pettersson-Kymmer, U., McCarthy, S. & Eriksson, J. & 136 others, , 2015, In: Nature. 526, 7571, p. 112-+

2012

FTO genotype is associated with phenotypic variability of body mass index

Yang, J., Loos, R., Powell, J., Medland, S., Speliotes, E., Chasman, D., Rose, L., Thorleifsson, G., Steinthorsdottir, V., Magi, R., Waite, L., Smith, A., Yerges-Armstrong, L., Monda, K., Hadley, D., Mahajan, A., Li, G., Kapur, K., Vitart, V. & Huffman, J. & 151 others, , 2012, In: Nature. 490, p. 267-272 6 p.

2004

Best Thesis project written second semester.

2005

Chemical engineering Department –  Universidad de los Andes

2010-2011

Best Master of Science manuscript written under the supervision – NIHES tutor Epidemiology Department ErasmusMC

2011

New Investigator Award – American Society of Bone and Mineral Research

2012

Travel Grant Plenary Poster – American Society of Bone and Mineral Research.

New Investigator Award – European Calcified Tissue Society

2013

New Investigator Award  – 6th International Conference of Children’s Bone Health

2014-2016

Best PhD Thesis Award –  Dutch Bone and Mineral Society NVCB

2015

New Investigator Award – 7th International Conference of Children’s Bone Health

Semifinalist for the 2015 Charles J. Epstein Trainee Award for Excellence in Human Genetics Research – 65th annual meeting of the American Society of Human Genetics

2016

ECTS Travel award – European Calcified Tissue Society

2017

Travel award ICCBH  – ICCBH 2017- Salzburg

2019

ECTS Travel award – European Calcified Tissue Society